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pentobarbital will minimize the extent or effect of amlodipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.Watch Closely (2)pentobarbital will reduce the extent or effect of buprenorphine, extended-acting injection by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. C